Get Rid of Pimples With the Best Spot Treatments for Acne

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There is nothing worse than pus-filled pimples and zits that pop up out of nowhere and make you want to hide behind your hands every time someone looks at your face. They’re not just uncomfortable, they’re embarrassing. But what if there was a way to treat those painful zits without resorting to any harsh chemicals or expensive procedures? Well, thanks to spot treatments for acne, now there is!

Acne spot treatments work by killing bacteria on the skin, drying out existing pimples, shrinking the size of pustules, and reducing redness caused by inflammation. They are often applied directly to blemishes but can also be used as part of a daily skincare routine. That said, we’ve scoured the internet and reviewed some of the premium spot treatments for acne in 2022 that’ll help you with embarrassing zits without overly drying out your skin.

Comparing the Leading Spot Treatment of 2022

Spot Treatment for Acne by Dots for Spots  —  Best Overall

A favorite among skincare gurus and beauty bloggers, Dot for Spots Spot Treatment for Acne is designed to target painful zits with pinpoint accuracy. These hydrocolloid patches gently absorb sebum and other impurities to diminish the acne blemishes while creating a protective barrier that guards against accidental picking and poking. The ultra-thin patch quickly adheres to the skin while the tapered edges prevent the puss from spreading to the surrounding area. 

Unlike traditional acne patches, these spot treatments for acne have a translucent center that turns opaque white, indicating that you have reached the saturation point and should remove the patch. Suitable for different skin types, these acne spot treatments are vegan-friendly and fragrance-free, so they won't irritate your skin or cause any allergic reactions. This product has earned its place as best overall on our list because of its gentle formula, effective results, and affordability. 


  • Reduce redness and inflammation
  • The tapered edge keeps grime out
  • Alcohol-free, non-irritating formula


  • Require 3-4 applications for deeper pimples

Mighty Patch Spot Treatment for Acne  —  Best for Whiteheads

Looking for an acne treatment that’ll suck the gunk out of your pimples without leaving a scar? Then try Might Patch Spot Treatment for Acne. Made from medical-grade hydrocolloid, these acne spot treatments offer superior adhesion to trap pus and impurities, providing you with smooth and clear skin within hours. 

Featuring a translucent matte finish, these patches blend in seamlessly into the skin while keeping other contaminants out. Even better, they are easy to remove so you don't have to worry about redness or inflammation either. This acne treatment patch is UV sterilized and allergy-tested, so it's safe for even the most sensitive skin types. Each package comes with 36 medium dots that are enough to keep your acne under control.


  • Quickly remove the pimples
  • Do not dry out the skin
  • Comes in an easy-peel perforated sheet


  • Not ideal for cystic acne

Neutrogena Spot Treatment for Acne  —  Best for Acne Scars

If you want to get rid of those stubborn acne spots, then Neutrogena Spot Treatment for Acne is just the right product for you. Infused with bacteria blasting ingredient benzoyl peroxide, this acne spot treatment unclogs pores to remove acne from the source while preventing future breakouts. Designed especially for acne-prone skin, this acne spot cream works on the toughest spots like backne and chin acne and can provide visible results within two hours of application. And don’t let its small size fool you. It still packs a punch when it comes to balancing those zit-zapping activities.


  • Shrink pimple within two hours
  • Lightweight gel formula for quick absorption
  • Dermatologist recommended solution


  • Not suitable for every skin type

Proactiv Spot Treatment for Acne  —  Travel-Friendly

Proactiv's acne spot treatment is a lifesaver for those who suffer from unexpected breakouts. Formulated it powerful blemish banishing ingredients including benzoyl peroxide and allantoin, this super-concentrated acne spot treatment absorbs excess oil from the skin to clear up the pimples and blemishes that have just surfaced, as well as deep-rooted breakouts that have been around for months. 

Additionally, this product is safe for all skin types, but what makes it stand out from the rest of the pack is that it soothes irritated and inflamed skin while providing much-needed hydration. Available in travel-friendly packaging, this spot acne treatment is perfect to help you get through those awkward moments when your skin starts acting up in public.


  • Can be used for different types of acne
  • Ultra-thin tip for precise application
  • Easy to use and store


  • Has an off-putting smell

La Roche-Posay Spot Treatment for Acne  —  Most Moisturizing

Laced with a hard-hitting combo of benzoyl peroxide and Lipo-Hydroxide acid, the LA Roche Posay acne spot treatment penetrates deep into the skin to fight off pimples before they push their way through the surface of the skin while shrinking the ones that have already popped up. Not only does it help with unclogging pores and clearing out the zits but also sloughs off dead skin and improves cell turnover rate. 

With its secret ingredient glycerin, this acne spot treatment combats excessive dryness and gives your skin a boost of hydration, so you can enjoy healthy-looking, dewy skin. The ultra-thin applicator tip allows for targeted application to acne spots and blemishes, while the unscented formula ensures it won't irritate sensitive skin. With a lightweight texture, it quickly absorbs into the skin without leaving a trace of greasiness, so you can quickly top it off with moisturizer and makeup!


  • Visibly reduce acne in three days
  • Fast absorbing formula
  • Oil-free and non-comedogenic
  • Available in two different sizes


  • Must be applied regularly for optimal results

Buyer’s Guide: Spot Treatment for Acne

There are different types of acne spot treatments available in the market right now that can put a buyer in a head-scratching situation. Some are designed purely as spot treatments while others are used in conjunction with facial cleansers or toners; still, others may even be considered “all-in-one” products that act as both treatment and prevention agents against future outbreaks!  To make sure you're using the right treatment for your needs, you should carefully consider the following factors:

Essential Ingredients To Look For in Spot Treatments for Acne

Salicylic acid

Salicylic acid is a beta-hydroxy acid that works by exfoliating dead skin cells from your pores which helps prevent clogged pores from forming blackheads and whiteheads without causing inflammation or dryness.

Benzoyl peroxide

Benzoyl peroxide is another popular ingredient used in over-the-counter spot treatments for acne because it kills bacteria on contact without harming healthy cells in your skin. Benzoyl peroxide comes in different strengths — 2.5% and 5% are most commonly used for treating mild acne — so read the label carefully before buying any product containing this ingredient. You may want to start with a lower concentration first, then gradually increase if needed. 


Sulfur is another common ingredient found in many over-the-counter acne treatments as well as prescription options. It works by killing bacteria that cause acne along with reducing inflammation and redness caused by pimples and cysts on your face. It also helps prevent future breakouts by unclogging pores and reducing oil production. 

How To Choose an Effective Acne Treatment?

Skin type

When choosing an acne treatment product, it's important to determine your skin type first. You may have oily or dry skin or a combination skin that is both oily and dry. If you have oily skin, you'll want to look for a product that contains salicylic acid or benzoyl peroxide as an active ingredient; these substances will help break down oil on your face. If you have dry skin, look for moisturizing ingredients like glycerin in your acne treatment product.

Acne severity

If you've only had a few pimples here and there, an over-the-counter medication may be all you need. On the other hand, if you have cystic acne or if it's not responding well to over-the-counter products like benzoyl peroxide or salicylic acid, you may need prescription medications like oral antibiotics or isotretinoin (commonly known as Accutane). Before buying any spot treatment, consult with your dermatologist.

Product concentration

The concentration of a product affects its effectiveness and other side effects such as dryness and flaking. Some products contain high concentrations of active ingredients like benzoyl peroxide, salicylic acid, or sulfur. Others only contain 1% of these ingredients and are marketed as "gentle" or "low-strength." 

The higher the concentration of active ingredients, the more effective the product will be at fighting acne. Some people have very sensitive skin, however, that cannot tolerate high concentrations of active ingredients. If this applies to you, look for a product with lower concentrations of benzoyl peroxide or salicylic acid.