

When Grey’s Anatomy premiered on March 27, 2005, TV was never the same. Fans immediately fell in love with Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, George O’Malley, Derek Shepherd, Miranda Bailey, and more. Grey’s Anatomy is now in its 17th season, and fans are still loving it as much as they did when it premiered all the way back in 2005.
Over the years, Grey’s Anatomy has shocked us with jaw-dropping twists, made us cry over heartbreaking deaths and breakups, and made us laugh and smile during the show’s happiest moments. Let’s take a look back at how the core cast members of Grey’s Anatomy have changed since their first day at Seattle Grace!
It’s wild to see the cast has changed from back then in 2005 to now. From Katherine Heigl, to T.R. Knight, to Eric Dane, to Sara Ramirez, these stars may not be on the show anymore, but they’re still near and dear to our hearts. The cast members have made amazing transformations and have gone on to star in other major movies and TV shows. Take a look through the gallery above to see more photos of the stars then and now!